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C. elegans possess a general program to enter cryptobiosis that allows dauer larvae to survive different kinds of abiotic stress.

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Gade,  Vamshidhar
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Traikov,  Sofia
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Kurzchalia,  Teymuras V.
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Gade, V., Traikov, S., Oertel, J., Fahmy, K., & Kurzchalia, T. V. (2020). C. elegans possess a general program to enter cryptobiosis that allows dauer larvae to survive different kinds of abiotic stress. Scientific reports, 10(1): 13466. doi:10.1038/s41598-020-70311-8.


Cite as: https://hdl.handle.net/21.11116/0000-0008-A27A-8
Abstract
All organisms encounter abiotic stress but only certain organisms are able to cope with extreme conditions and enter into cryptobiosis (hidden life). Previously, we have shown that C. elegans dauer larvae can survive severe desiccation (anhydrobiosis), a specific form of cryptobiosis. Entry into anhydrobiosis is preceded by activation of a set of biochemical pathways by exposure to mild desiccation. This process called preconditioning induces elevation of trehalose, intrinsically disordered proteins, polyamines and some other pathways that allow the preservation of cellular functionality in the absence of water. Here, we demonstrate that another stress factor, high osmolarity, activates similar biochemical pathways. The larvae that acquired resistance to high osmotic pressure can also withstand desiccation. In addition, high osmolarity significantly increases the biosynthesis of glycerol making larva tolerant to freezing. Thus, to survive abiotic stress, C. elegans activates a combination of genetic and biochemical pathways that serve as a general survival program.