English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse
  1. View item / 
  2. Item Summary

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

Structure, Biosynthesis, and Occurrence of Bacterial Pyrrolizidine Alkaloids

MPS-Authors
There are no MPG-Authors in the publication available
External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Schimming, O., Challinor, V. L., Tobias, N. J., Adihou, H., Gruen, P., Poeschel, L., et al. (2015). Structure, Biosynthesis, and Occurrence of Bacterial Pyrrolizidine Alkaloids. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 54(43), 12702-12705. doi:10.1002/anie.201504877.


Cite as: https://hdl.handle.net/21.11116/0000-000A-0532-8
Abstract
Pyrrolizidine alkaloids (PAs) are widespread plant natural products with potent toxicity and bioactivity. Herein, the identification of bacterial PAs from entomopathogenic bacteria using differential analysis by 2D NMR spectroscopy (DANS) and mass spectrometry is described. Their biosynthesis was elucidated to involve a non-ribosomal peptide synthetase. The occurrence of these biosynthesis gene clusters in Gram-negative and Gram-positive bacteria indicates an important biological function in bacteria.