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Mitochondrial hitch-hiking of Pink1 mRNA supports axonal mitophagy

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Harbauer,  Angelika B.
Max Planck Research Group: Neurometabolism / Harbauer, MPI of Neurobiology, Max Planck Society;

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https://doi.org/10.1080/15548627.2022.2070332
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Citation

Harbauer, A. B., & Schwarz, T. L. (2022). Mitochondrial hitch-hiking of Pink1 mRNA supports axonal mitophagy. Autophagy, 18(12), 3048-3049.


Cite as: https://hdl.handle.net/21.11116/0000-000A-5F08-4
Abstract
Mitostasis, the process of mitochondrial maintenance by biogenesis and degradative mechanisms, is challenged by the extreme length of axons. PINK1 (PTEN induced putative kinase 1) is a mitochondrial protein that targets damaged mitochondria for mitophagy. In reconciling the short half-life of PINK1 with the need for mitophagy of damaged axonal mitochondria, we found that axonal mitophagy depends on local translation of the Pink1 mRNA. Using live-cell imaging, we detected co-transport of the Pink1 mRNA on mitochondria in neurons, which is crucial for mitophagy in distal parts of the cell. Here we discuss how the coupling of the transcript of a short-lived mitochondrial protein to the movement of its target organelles contributes to our understanding of mitostasis in neurons.