Gene silencing and sex determination by programmed DNA elimination in parasitic 
nematodes

Streit, A; Wang, J; Kang, Y; Davis, RE

doi:10.1016/j.mib.2016.05.012

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Gene silencing and sex determination by programmed DNA elimination in parasitic nematodes

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Streit, A
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;
Parasitic Nematode Group, Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Streit, A., Wang, J., Kang, Y., & Davis, R. (2016). Gene silencing and sex determination by programmed DNA elimination in parasitic nematodes. Current Opinion in Microbiology, 32, 120-127. doi:10.1016/j.mib.2016.05.012.

Cite as: https://hdl.handle.net/21.11116/0000-000A-8785-7

Abstract

Maintenance of genome integrity is essential. However, programmed DNA elimination removes specific DNA sequences from the genome during development. DNA elimination occurs in unicellular ciliates and diverse metazoa ranging from nematodes to vertebrates. Two distinct groups of nematodes use DNA elimination to silence germline-expressed genes in the soma (ascarids) or for sex determination (Strongyloides spp.). Data suggest that DNA elimination likely evolved independently in these nematodes. Recent studies indicate that differential CENP-A deposition within chromosomes defines which sequences are retained and lost during Ascaris DNA elimination. Additional studies are needed to determine the distribution, functions, and mechanisms of DNA elimination in nematodes.