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Journal Article

Templated self-replication in biomimetic systems

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Le Vay,  K.
Mutschler, Hannes / Biomimetic Systems, Max Planck Institute of Biochemistry, Max Planck Society;

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Weise,  Laura Isabel
Mutschler, Hannes / Biomimetic Systems, Max Planck Institute of Biochemistry, Max Planck Society;

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Libicher,  K.
Mutschler, Hannes / Biomimetic Systems, Max Planck Institute of Biochemistry, Max Planck Society;

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Mutschler,  Hannes
Mutschler, Hannes / Biomimetic Systems, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Le Vay, K., Weise, L. I., Libicher, K., Mascarenhas, J., & Mutschler, H. (2019). Templated self-replication in biomimetic systems. Advanced Biosystems, 3(6): 1800313. doi:10.1002/adbi.201800313.


Cite as: https://hdl.handle.net/21.11116/0000-000A-AAE4-5
Abstract
A key characteristic of living systems is the storage and replication of information, and as such the development of self-replicating systems capable of heredity is of great importance to the fields of synthetic biology and origin of life research. In this review, the design and implementation of self-replicating systems in the context of bottom-up synthetic biology is discussed, with a particular focus on nucleic acid-based replication including nonenzymatic systems, ribozyme-based systems, and complex in vitro translation coupled RNA and DNA replication. The current state and remaining challenges of the respective fields are discussed, and the potential of individual replicators for synthetic biology applications such as the creation of artificial life capable of Darwinian evolution is also summarized.