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Journal Article

Lithium can mildly increase health during ageing but not lifespan in mice

MPS-Authors
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Nespital,  T.
Department Partridge - Biological Mechanisms of Ageing, Max Planck Institute for Biology of Ageing, Max Planck Society;

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Neuhaus,  B.
Department Partridge - Biological Mechanisms of Ageing, Max Planck Institute for Biology of Ageing, Max Planck Society;

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Mesaros,  A.
Phenotyping, Core Facilities, Max Planck Institute for Biology of Ageing, Max Planck Society;

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Pahl,  A.
Department Partridge - Biological Mechanisms of Ageing, Max Planck Institute for Biology of Ageing, Max Planck Society;

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Partridge,  L.
Department Partridge - Biological Mechanisms of Ageing, Max Planck Institute for Biology of Ageing, Max Planck Society;

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https://www.ncbi.nlm.nih.gov/pubmed/34532960
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Citation

Nespital, T., Neuhaus, B., Mesaros, A., Pahl, A., & Partridge, L. (2021). Lithium can mildly increase health during ageing but not lifespan in mice. Aging Cell, 10(20), e13479. doi:10.1111/acel.13479.


Cite as: https://hdl.handle.net/21.11116/0000-000A-FA68-8
Abstract
Lithium is a nutritional trace element, used clinically as an anti-depressant. Preclinically, lithium has neuroprotective effects in invertebrates and mice, and it can also extend lifespan in fission yeast, C. elegans and Drosophila. An inverse correlation of human mortality with the concentration of lithium in tap water suggests a possible, evolutionarily conserved mechanism mediating longevity. Here, we assessed the effects of lithium treatment on lifespan and ageing parameters in mice. Lithium has a narrow therapeutic dose range, and overdosing can severely affect organ health. Within the tolerable dosing range, we saw some mildly positive effects of lithium on health span but not on lifespan.