Cradle-loop barrels and the concept of metafolds in protein classification by 
natural descent

Alva, V; Koretke, KK; Coles, M; Lupas, AN

doi:10.1016/j.sbi.2008.02.006

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Cradle-loop barrels and the concept of metafolds in protein classification by natural descent

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Alva, V
Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;

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Coles, M
Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;

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Lupas, AN
Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Alva, V., Koretke, K., Coles, M., & Lupas, A. (2008). Cradle-loop barrels and the concept of metafolds in protein classification by natural descent. Current Opinion in Structural Biology, 18(3), 358-365. doi:10.1016/j.sbi.2008.02.006.

Cite as: https://hdl.handle.net/21.11116/0000-000A-F23E-0

Abstract

Current classification systems for protein structure show many inconsistencies both within and between systems. The metafold concept was introduced to identify fold similarities by consensus and thus provide a more unified view of fold space. Using cradle-loop barrels as an example, we propose to use the metafold as the next hierarchical level above the fold, encompassing a group of topologically related folds for which a homologous relationship has been substantiated. We see this as an important step on the way to a classification of proteins by natural descent.