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Journal Article

Quantitative phase imaging through an ultra-thin lensless fiber endoscope

MPS-Authors
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Goswami,  Ruchi
Guck Division, Max Planck Institute for the Science of Light, Max Planck Society;

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Girardo,  Salvatore
Guck Division, Max Planck Institute for the Science of Light, Max Planck Society;

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Guck,  Jochen
Guck Division, Max Planck Institute for the Science of Light, Max Planck Society;
Max-Planck-Zentrum für Physik und Medizin, Max Planck Institute for the Science of Light, Max Planck Society;
Technische Universität Dresden;

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Light Sci Appl 2022 Sun.pdf
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Citation

Sun, J., Wu, J., Goswami, R., Girardo, S., Cao, L., Guck, J., et al. (2022). Quantitative phase imaging through an ultra-thin lensless fiber endoscope. Light: Science & Applications, 11: 204. doi:10.1038/s41377-022-00898-2.


Cite as: https://hdl.handle.net/21.11116/0000-000A-FF32-F
Abstract
Quantitative phase imaging (QPI) is a label-free technique providing both morphology and quantitative biophysical information in biomedicine. However, applying such a powerful technique to in vivo pathological diagnosis remains challenging. Multi-core fiber bundles (MCFs) enable ultra-thin probes for in vivo imaging, but current MCF imaging techniques are limited to amplitude imaging modalities. We demonstrate a computational lensless microendoscope that uses an ultra-thin bare MCF to perform quantitative phase imaging with microscale lateral resolution and nanoscale axial sensitivity of the optical path length. The incident complex light field at the measurement side is precisely reconstructed from the far-field speckle pattern at the detection side, enabling digital refocusing in a multi-layer sample without any mechanical movement. The accuracy of the quantitative phase reconstruction is validated by imaging the phase target and hydrogel beads through the MCF. With the proposed imaging modality, three-dimensional imaging of human cancer cells is achieved through the ultra-thin fiber endoscope, promising widespread clinical applications.