Wunen, a Drosophila lipid phosphate phosphatase, is required for septate 
junction mediated barrier function

Renault, AD; Ile, K; Tripathy, R; Goldfinger, V

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Meeting Abstract

Wunen, a Drosophila lipid phosphate phosphatase, is required for septate junction mediated barrier function

MPS-Authors

/persons/resource/persons275483

Renault, AD
Research Group Extracellular Lipid Signaling in Drosophila Development, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons275762

Ile, K
Research Group Extracellular Lipid Signaling in Drosophila Development, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons275554

Tripathy, R
Research Group Extracellular Lipid Signaling in Drosophila Development, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons275812

Goldfinger, V
Research Group Extracellular Lipid Signaling in Drosophila Development, Max Planck Institute for Developmental Biology, Max Planck Society;

External Resource

http://www.drosophila-conf.org/2012/book/Abstracts_Web.pdf
(Abstract)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Renault, A., Ile, K., Tripathy, R., & Goldfinger, V. (2012). Wunen, a Drosophila lipid phosphate phosphatase, is required for septate junction mediated barrier function. In 53rd Annual Drosophila Research Conference 2012 (pp. 165).

Cite as: https://hdl.handle.net/21.11116/0000-000B-4349-8

Abstract

Lipid phosphate phosphatases (LPPs) are integral membrane enzymes than can regulate the levels of bioactive lipids such as sphingosine 1-phosphate and
lysophosphatidic acid. The Drosophila LPPs wunen (wun) and wunen2 (wun2) have a well-established role in regulating the survival and migration of germ
cells. We now show that Wun has an independent and essential cell autonomous role in development of the trachea. In particular Wun is required to maintain
septate junction (SJ) paracellular barrier function, loss of which causes failure to accumulate critical luminal components. We find the integrity of the blood
brain barrier is also lost in wun mutants indicating a general role for LPPs in SJ function. Furthermore by comparing the rescue ability of different LPP
homologs we show that Wun function in the trachea is distinct from its role in germ cell migration, although in both cases, catalytic activity is essential for function.