Mitochondria shed their outer membrane in response to infection-induced stress

Li, X.; Straub, J.; Medeiros, T. C.; Mehra, C.; den Brave, F.; Peker, E.; Atanassov, I.; Stillger, K.; Michaelis, J. B.; Burbridge, E.; Adrain, C.; Munch, C.; Riemer, J.; Becker, T.; Pernas, L.

doi:10.1126/science.abi4343

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Mitochondria shed their outer membrane in response to infection-induced stress

MPS-Authors

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Li, X.
Pernas – Metabolism of Infection, Max Planck Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society;

/persons/resource/persons284246

Straub, J.
Pernas – Metabolism of Infection, Max Planck Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society;

/persons/resource/persons278223

Medeiros, T. C.
Pernas – Metabolism of Infection, Max Planck Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society;

/persons/resource/persons278108

Mehra, C.
Pernas – Metabolism of Infection, Max Planck Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society;

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Atanassov, I.
Proteomics, Core Facilities, Max Planck Institute for Biology of Ageing, Max Planck Society;

/persons/resource/persons278111

Pernas, L.
Pernas – Metabolism of Infection, Max Planck Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society;

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https://www.ncbi.nlm.nih.gov/pubmed/35025629
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引用

Li, X., Straub, J., Medeiros, T. C., Mehra, C., den Brave, F., Peker, E., Atanassov, I., Stillger, K., Michaelis, J. B., Burbridge, E., Adrain, C., Munch, C., Riemer, J., Becker, T., & Pernas, L. (2022). Mitochondria shed their outer membrane in response to infection-induced stress. Science, 375(6577), eabi4343. doi:10.1126/science.abi4343.

引用: https://hdl.handle.net/21.11116/0000-000B-B707-F

要旨

The outer mitochondrial membrane (OMM) is essential for cellular homeostasis. Yet little is known of the mechanisms that remodel it during natural stresses. We found that large "SPOTs" (structures positive for OMM) emerge during Toxoplasma gondii infection in mammalian cells. SPOTs mediated the depletion of the OMM proteins mitofusin 1 and 2, which restrict parasite growth. The formation of SPOTs depended on the parasite effector TgMAF1 and the host mitochondrial import receptor TOM70, which is required for optimal parasite proliferation. TOM70 enabled TgMAF1 to interact with the host OMM translocase SAM50. The ablation of SAM50 or the overexpression of an OMM-targeted protein promoted OMM remodeling independently of infection. Thus, Toxoplasma hijacks the formation of SPOTs, a cellular response to OMM stress, to promote its growth.