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Journal Article

Disrupted resting-sate brain network dynamics in children born extremely preterm

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Deco,  Gustavo
Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain;
School of Psychological Sciences, Monash University, Melbourne, Australia;
Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain;
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Padilla_2023.pdf
(Publisher version), 750KB

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Padilla_2023_Suppl.pdf
(Supplementary material), 463KB

Citation

Padilla, N., Escrichs, A., del Agua, E., Kringelbach, M., Donaire, A., Deco, G., et al. (2023). Disrupted resting-sate brain network dynamics in children born extremely preterm. Cerebral Cortex, 33(13), 8101-8109. doi:10.1093/cercor/bhad101.


Cite as: https://hdl.handle.net/21.11116/0000-000D-0A1B-B
Abstract
The developing brain has to adapt to environmental and intrinsic insults after extremely preterm (EPT) birth. Ongoing maturational processes maximize their fit to the environment and this can provide a substrate for neurodevelopmental failures. Resting-state functional magnetic resonance imaging was used to scan 33 children born EPT, at < 27 weeks of gestational age, and 26 full-term controls at 10 years of age. We studied the capability of a brain area to propagate neural information (intrinsic ignition) and its variability across time (node-metastability). This framework was computed for the dorsal attention network (DAN), frontoparietal, default-mode network (DMN), and the salience, limbic, visual, and somatosensory networks. The EPT group showed reduced intrinsic ignition in the DMN and DAN, compared with the controls, and reduced node-metastability in the DMN, DAN, and salience networks. Intrinsic ignition and node-metastability values correlated with cognitive performance at 12 years of age in both groups, but only survived in the term group after adjustment. Preterm birth disturbed the signatures of functional brain organization at rest in 3 core high-order networks: DMN, salience, and DAN. Identifying vulnerable resting-state networks after EPT birth may lead to interventions that aim to rebalance brain function.