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Journal Article

Author Correction: Effects of drought and recovery on soil volatile organic compound fluxes in an experimental rainforest

MPS-Authors
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Pfannerstill,  Eva Y.
Atmospheric Chemistry, Max Planck Institute for Chemistry, Max Planck Society;

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Klüpfel,  Thomas
Atmospheric Chemistry, Max Planck Institute for Chemistry, Max Planck Society;

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Byron,  Joseph
Atmospheric Chemistry, Max Planck Institute for Chemistry, Max Planck Society;

/persons/resource/persons101364

Williams,  Jonathan
Atmospheric Chemistry, Max Planck Institute for Chemistry, Max Planck Society;

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https://www.nature.com/articles/s41467-023-42207-4.pdf
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Citation

Pugliese, G., Ingrisch, J., Meredith, L. K., Pfannerstill, E. Y., Klüpfel, T., Meeran, K., et al. (2023). Author Correction: Effects of drought and recovery on soil volatile organic compound fluxes in an experimental rainforest. Nature Communications, 14: 6372. doi:10.1038/s41467-023-42207-4.


Cite as: https://hdl.handle.net/21.11116/0000-000D-F35C-A
Abstract
The molecular architecture of alpha -Synuclein (alpha -Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. alpha -Syn inclusions were long thought to consist mainly of alpha -Syn fibrils, but recent reports pointed to intracellular membranes as the major inclusion component. Here, we use cryo-electron tomography (cryo-ET) to image neuronal alpha -Syn inclusions in situ at molecular resolution. We show that inclusions seeded by alpha -Syn aggregates produced recombinantly or purified from patient brain consist of alpha -Syn fibrils crisscrossing a variety of cellular organelles. Using gold-labeled seeds, we find that aggregate seeding is predominantly mediated by small alpha -Syn fibrils, from which cytoplasmic fibrils grow unidirectionally. Detailed analysis of membrane interactions revealed that alpha -Syn fibrils do not contact membranes directly, and that alpha -Syn does not drive membrane clustering. Altogether, we conclusively demonstrate that neuronal alpha -Syn inclusions consist of alpha -Syn fibrils intermixed with membranous organelles, and illuminate the mechanism of aggregate seeding and cellular interaction. The molecular architecture of alpha -Synuclein (alpha -Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. Here, authors use cryo-electron tomography to image neuronal alpha -Syn inclusions in situ and find that inclusions consist of alpha -Syn fibrils intermixed with cellular organelles without interacting directly.