TRIM for Tissue Specificity

Hartmann, MD

doi:10.1021/acsmedchemlett.3c00504

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TRIM for Tissue Specificity

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Hartmann, MD
Molecular Recognition and Catalysis Group, Department Protein Evolution, Max Planck Institute for Biology Tübingen, Max Planck Society;
Department Protein Evolution, Max Planck Institute for Biology Tübingen, Max Planck Society;

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Citation

Hartmann, M. (2024). TRIM for Tissue Specificity. ACS Medicinal Chemistry Letters, 15(1), 4-5. doi:10.1021/acsmedchemlett.3c00504.

Cite as: https://hdl.handle.net/21.11116/0000-000E-1772-8

Abstract

Tissue-specific manipulation of proteins is a long-standing objective in the field of targeted protein degradation, but still a distant prospect. Currently, the most successfully employed E3 ubiquitin ligases belong to the most ubiquitously expressed representatives. Unlocking of the TRIM58 ligase might represent a promising step toward tissue-specific PROTACs and molecular glue degraders.