Usefulness and limitations of linear approximations to the understanding of Ca++
 signals

Neher, E.

doi:10.1016/S0143-4160(98)90058-6

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Usefulness and limitations of linear approximations to the understanding of Ca⁺⁺ signals

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Neher, E.
Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society;

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Citation

Neher, E. (1998). Usefulness and limitations of linear approximations to the understanding of Ca⁺⁺ signals. Cell Calcium, 24(5-6), 345-357. doi:10.1016/S0143-4160(98)90058-6.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-FDA4-0

Abstract

Simple approximations to some limiting cases of Ca++ signalling provide insight into the complex problems of buffered diffusion and of Ca++ homeostasis in the presence of buffers. Three cases are presented, where the influence of Ca++ buffers can readily be understood in the limit of small signals: the return of global cellular [Ca++] following a short stimulus in a ‘Single Compartment’, buffered diffusion along a cylindrical axon in the ‘Rapid Buffer Approximation’, and nonequilibrium microdomains of elevated [Ca++] in the immediate vicinity of open Ca++ channels.