Cellular immunodepression preceding infectious complications after acute 
ischemic stroke in humans

Haeusler, K. G.; Schmidt, W. U.; Foehring, F.; Meisel, C.; Helms, T.; Jungehulsing, G. J.; Nolte, C. H.; Schmolke, K.; Wegner, B.; Meisel, A.; Dirnagl, U.; Villringer, Arno; Volk, H. D.

doi:10.1159/000111499

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Cellular immunodepression preceding infectious complications after acute ischemic stroke in humans

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Haeusler, K. G., Schmidt, W. U., Foehring, F., Meisel, C., Helms, T., Jungehulsing, G. J., et al. (2008). Cellular immunodepression preceding infectious complications after acute ischemic stroke in humans. Cerebrovascular Diseases, 25(1-2), 50-58. doi:10.1159/000111499.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-A345-E

Abstract

B a c k g r o u n d : We have recently shown that ischemic stroke causes a stress-mediator-induced long-lasting immuno- depressive state in mice. Methods: Using head magnetic resonance imaging and standardized immunoassays, we prospectively investigated whether poststroke immuno- depression is also seen in humans. Results: Compared to healthy volunteers (n = 30), a rapid depression of lympho- cyte counts and a functional deactivation of monocytes and T helper type 1 cells was observed in acute stroke patients (SP; n = 40). Immunodepression was more pronounced in patients with severe clinical deficit or large infarction. On ad- mission the combination of mono cytic tumor necrosis factor release ex vivo and the National Institute of Health Stroke Scale score were the best predictors for nosocomial infec- tion, preferentially affecting older SP. Conclusion: Our data provide evidence for an immediate suppression of cell-me- diated immune responses after ischemic stroke in humans.