Real-Time fMRI Brain Mapping in Animals

Choi, S; Takahashi, K; Jiang, Y; Köhler, S; Zeng, H; Wang, Q; Ma, Y; Yu, X

doi:10.3791/61463

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Real-Time fMRI Brain Mapping in Animals

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Choi, S
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons214937

Takahashi, K
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons214544

Jiang, Y
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons214943

Zeng, H
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons251740

Wang, Q
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons251744

Ma, Y
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons133486

Yu, X
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://www.jove.com/t/61463/real-time-fmri-brain-mapping-in-animals
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Citation

Choi, S., Takahashi, K., Jiang, Y., Köhler, S., Zeng, H., Wang, Q., et al. (2020). Real-Time fMRI Brain Mapping in Animals. Journal of Visualized Experiments, 2020(163). doi:10.3791/61463.

Cite as: https://hdl.handle.net/21.11116/0000-0007-3464-E

Abstract

Dynamic fMRI responses vary largely according to the physiological conditions of animals either under anesthesia or in awake states. We developed a real-time fMRI platform to guide experimenters to monitor fMRI responses instantaneously during acquisition, which can be used to modify the physiology of animals to achieve desired hemodynamic responses in animal brains. The real-time fMRI set-up is based on a 14.1T preclinical MRI system, enabling the real-time mapping of dynamic fMRI responses in the primary forepaw somatosensory cortex (FP-S1) of anesthetized rats. Instead of a retrospective analysis to investigate confounding sources leading to the variability of fMRI signals, the real-time fMRI platform provides a more effective scheme to identify dynamic fMRI responses using customized macro-functions and a common neuroimage analysis software in the MRI system. Also, it provides immediate troubleshooting feasibility and a real-time biofeedback stimulation paradigm for brain functional studies in animals.