Optogenetic fPET/fMRI Reveals Distinct Roles of the Substania Nigra in Motor 
and Cognitive Processes

Ma, Y; Bravo, F; Haas, F; Ionescu, TM; Herfert, K

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Optogenetic fPET/fMRI Reveals Distinct Roles of the Substania Nigra in Motor and Cognitive Processes

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Ma, Y
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://www.tuebingen.mpg.de/224560/DACH-ISMRM2024_Proceedings.pdf
(Abstract)

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Citation

Ma, Y., Bravo, F., Haas, F., Ionescu, T., & Herfert, K. (2024). Optogenetic fPET/fMRI Reveals Distinct Roles of the Substania Nigra in Motor and Cognitive Processes. Poster presented at DACH-ISMRM Annual Meeting 2024, Tübingen, Germany.

Cite as: https://hdl.handle.net/21.11116/0000-000F-C067-4

Abstract

In this study we used data from simultaneous [18F]FDG-PET/BOLD-fMRI experiments to investigate how optogenetic stimulation of the substantia nigra pars compacta (SNc) in rats affects brain functional (FC) and metabolic connectivity (MC). Our data show an isolation of the striatum during stimulation and negative correlations of the SNc with cortical and cerebellar regions, supporting evidence of a Cb-SNc connection.