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Journal Article

Rewiring Escherichia coli to transform formate into methyl groups

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Satanowski,  Ari
Cellular Operating Systems, Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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Erb,  Tobias J.       
Cellular Operating Systems, Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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Citation

Mohr, M. K. F., Satanowski, A., Lindner, S. N., Erb, T. J., & Andexer, J. N. (2025). Rewiring Escherichia coli to transform formate into methyl groups. Microbial Cell Factories, 24(1): 55. doi:10.1186/s12934-025-02674-4.


Cite as: https://hdl.handle.net/21.11116/0000-0010-E385-7
Abstract
Biotechnological applications are steadily growing and have become an important tool to reinvent the synthesis of chemicals and pharmaceuticals for lower dependence on fossil resources. In order to sustain this progression, new feedstocks for biotechnological hosts have to be explored. One-carbon (C1-)compounds, including formate, derived from CO2 or organic waste are accessible in large quantities with renewable energy, making them promising candidates. Previous studies showed that introducing the formate assimilation machinery from Methylorubrum extorquens into Escherichia coli allows assimilation of formate through the C1-tetrahydrofolate (C1-H4F) metabolism. Applying this route for formate assimilation, we here investigated utilisation of formate for the synthesis of value-added building blocks in E. coli using S-adenosylmethionine (SAM)-dependent methyltransferases (MT).