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  Implications of the thyroid hormone on neuronal development with special emphasis on the calmodulin-kinase IV pathway.

Krebs, J. (2017). Implications of the thyroid hormone on neuronal development with special emphasis on the calmodulin-kinase IV pathway. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1864(6), 877-882. doi:10.1016/j.bbamcr.2016.12.004.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-5A3E-C Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-80C1-8
Genre: Journal Article

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 Creators:
Krebs, J.1, Author              
Affiliations:
1Department of NMR Based Structural Biology, MPI for biophysical chemistry, Max Planck Society, ou_578567              

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Free keywords: Thyroid hormone; CaMKIV; PMCA1a; Alternative splicing; Neuronal development
 Abstract: Thyroid hormones influence brain development through regulation of gene expression. This is especially true for Ca2 +-dependent regulation since a major pathway is controlled by the Ca2 +/calmodulin-dependent protein kinase IV (CaMKIV) which in turn is induced by the thyroid hormone T3. In addition, CaMKIV is involved in regulation of alternative splicing of a number of protein isoforms, among them PMCA1a, the neuronal specific isoform of the plasma membrane calcium pump. On the other hand, hypothyroidism or CaMKIV deficiency can have a severe influence on brain development. This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech.

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Language(s): eng - English
 Dates: 2016-12-082017-06
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.bbamcr.2016.12.004
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Title: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Source Genre: Journal
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Pages: - Volume / Issue: 1864 (6) Sequence Number: - Start / End Page: 877 - 882 Identifier: -