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  After-effects of 10 Hz tACS over the prefrontal cortex on phonological word decisions

Moliadze, V., Sierau, L., Lyzhko, E., Stenner, T., Werchowski, M., Siniatchkin, M., et al. (2019). After-effects of 10 Hz tACS over the prefrontal cortex on phonological word decisions. Brain Stimulation, 12(6), 1464-1474. doi:10.1016/j.brs.2019.06.021.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0003-D058-F Version Permalink: http://hdl.handle.net/21.11116/0000-0005-4684-7
Genre: Journal Article

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 Creators:
Moliadze, Vera1, Author
Sierau, Leon1, Author
Lyzhko, Ekaterina2, 3, Author
Stenner, Tristan1, Author
Werchowski, Michael1, Author
Siniatchkin, Michael1, 4, Author
Hartwigsen, Gesa5, Author              
Affiliations:
1Institute of Medical Psychology and Medical Sociology, University Hospital of Schleswig-Holstein, Kiel, Germany, ou_persistent22              
2Department of Pediatric and Adolescent Medicine, University Hospital of Schleswig-Holstein, Kiel, Germany, ou_persistent22              
3Keldysh Institute of Applied Mathematics, Russian Academy of Sciences, Moscow, Russia, ou_persistent22              
4Clinic for Child and Adolescent Psychiatry and Psychotherapy, Medical Center Bethel, Bielefeld, Germany, ou_persistent22              
5Lise Meitner Research Group Cognition and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3025665              

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Free keywords: Alpha; Prefrontal cortex; Plasticity; Language; Non-invasive brain stimulation
 Abstract: Introduction Previous work in the language domain has shown that 10 Hz rTMS of the left or right posterior inferior frontal gyrus (pIFG) in the prefrontal cortex impaired phonological decision-making, arguing for a causal contribution of the bilateral pIFG to phonological processing. However, the neurophysiological correlates of these effects are unclear. The present study addressed the question whether neural activity in the prefrontal cortex could be modulated by 10 Hz tACS and how this would affect phonological decisions. Methods In three sessions, 24 healthy participants received tACS at 10 Hz or 16.18 Hz (control frequency) or sham stimulation over the bilateral prefrontal cortex before task processing. Resting state EEG was recorded before and after tACS. We also recorded EEG during task processing. Results Relative to sham stimulation, 10 Hz tACS significantly facilitated phonological response speed. This effect was task-specific as tACS did not affect a simple control task. Moreover, 10 Hz tACS significantly increased theta power during phonological decisions. The individual increase in theta power was positively correlated with the behavioral facilitation after 10 Hz tACS. Conclusion Our results show a facilitation of phonological decisions after 10 Hz tACS over the bilateral prefrontal cortex. This might indicate that 10 Hz tACS increased task-related activity in the stimulated area to a level that was optimal for phonological performance. The significant correlation with the individual increase in theta power suggests that the behavioral facilitation might be related to increased theta power during language processing.

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Language(s): eng - English
 Dates: 2019-05-132018-10-042019-06-182019-06-202019-11
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.brs.2019.06.021
Other: Epub 2019
PMID: 31278060
 Degree: -

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Funding organization : Max Planck Society
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Grant ID : HA 6314/3-1 ; HA 6314/4-1
Funding program : -
Funding organization : German Research Foundation (DFG)

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Title: Brain Stimulation
  Abbreviation : Brain Stimul
Source Genre: Journal
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Pages: - Volume / Issue: 12 (6) Sequence Number: - Start / End Page: 1464 - 1474 Identifier: ISSN: 1935-861X
CoNE: https://pure.mpg.de/cone/journals/resource/1935-861X