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  Cortical grey matter mediates increases in model-based control and learning from positive feedback from adolescence to adulthood

Scholz, V., Waltmann, M., Herzog, N., Reiter, A., Horstmann, A., & Deserno, L. (2023). Cortical grey matter mediates increases in model-based control and learning from positive feedback from adolescence to adulthood. The Journal of Neuroscience, 43(12), 2178-2189. doi:10.1523/JNEUROSCI.1418-22.2023.

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Scholz, Vanessa1, 2, Author
Waltmann, Maria1, 3, Author                 
Herzog, Nadine3, 4, Author                 
Reiter, Andrea1, 5, Author
Horstmann, Annette3, 4, 6, Author                 
Deserno, Lorenz1, 3, 4, 7, Author                 
1Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital Würzburg, Germany, ou_persistent22              
2Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
5Volition and Cognitive Control, TU Dresden, Germany, ou_persistent22              
6Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland, ou_persistent22              
7Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Dresden, Germany, ou_persistent22              


Free keywords: Adolescence; Development; Model-based control; Punishment learning; Reinforcement learning; Reward learning
 Abstract: Cognition and brain structure undergo significant maturation from adolescence into adulthood. Model-based (MB) control is known to increase across development, which is mediated by cognitive abilities. Here, we asked two questions unaddressed in previous developmental studies. First, what are the brain structural correlates of age-related increases in MB control? Second, how are age-related increases in MB control from adolescence to adulthood influenced by motivational context? A human developmental sample (n = 103; age, 12-50, male/female, 55:48) completed structural MRI and an established task to capture MB control. The task was modified with respect to outcome valence by including (1) reward and punishment blocks to manipulate the motivational context and (2) an additional choice test to assess learning from positive versus negative feedback. After replicating that an age-dependent increase in MB control is mediated by cognitive abilities, we demonstrate first-time evidence that gray matter density (GMD) in the parietal cortex mediates the increase of MB control with age. Although motivational context did not relate to age-related changes in MB control, learning from positive feedback improved with age. Meanwhile, negative feedback learning showed no age effects. We present a first report that an age-related increase in positive feedback learning was mediated by reduced GMD in the parietal, medial, and dorsolateral prefrontal cortex. Our findings indicate that brain maturation, putatively reflected in lower GMD, in distinct and partially overlapping brain regions could lead to a more efficient brain organization and might thus be a key developmental step toward age-related increases in planning and value-based choice.


Language(s): eng - English
 Dates: 2022-12-202022-07-212023-01-132023-02-232023-03-22
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1523/JNEUROSCI.1418-22.2023
Other: epub 2023
PMID: 36823039
PMC: PMC10039741
 Degree: -



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Project name : IFB Adiposity Diseases
Grant ID : 01EO150
Funding program : -
Funding organization : Federal Ministry of Education and Research (BMBF)
Project name : Collaborative Research Centre 265 “Losing and Regaining Control over drug intake”
Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : RE 4449/1-1; SFB 940-3/B7; RTG-2660/B2
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Brain and Behavior Research Foundation (BBRF)

Source 1

Title: The Journal of Neuroscience
  Other : The Journal of Neuroscience: the Official Journal of the Society for Neuroscience
  Abbreviation : J. Neurosci.
Source Genre: Journal
Publ. Info: Washington, DC : Society of Neuroscience
Pages: - Volume / Issue: 43 (12) Sequence Number: - Start / End Page: 2178 - 2189 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1