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  Neonatal brain dynamic functional connectivity in term and preterm infants and its association with early childhood neurodevelopment

França, L. G. S., Ciarrusta, J., Gale-Grant, O., Fenn-Moltu, S., Fitzgibbon, S., Chew, A., et al. (2024). Neonatal brain dynamic functional connectivity in term and preterm infants and its association with early childhood neurodevelopment. Nature Communications, 15(1): 16. doi:10.1038/s41467-023-44050-z.

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Item Permalink: https://hdl.handle.net/21.11116/0000-000D-ACF6-C Version Permalink: https://hdl.handle.net/21.11116/0000-000F-0F14-B
Genre: Journal Article

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 Creators:
França, Lucas G. S.1, 2, 3, Author
Ciarrusta, Judit1, 2, Author
Gale-Grant, Oliver1, 2, Author
Fenn-Moltu, Sunniva1, 2, Author
Fitzgibbon, Sean4, Author
Chew, Andrew2, Author
Falconer, Shona2, Author
Dimitrova, Ralica1, 2, Author
Cordero-Grande, Lucilio2, 5, 6, Author
Price, Anthony N.2, Author
Hughes, Emer2, Author
O'Muircheartaigh, Jonathan1, 2, 7, Author
Duff, Eugene4, 8, 9, Author
Tuulari, Jetro J.10, 11, 12, Author
Deco, Gustavo13, 14, 15, 16, Author           
Counsell, Serena J.2, Author
Hajnal, Joseph V.2, Author
Nosarti, Chiara2, 17, Author
Arichi, Tomoki2, 7, 18, 19, Author
Edwards, A. David2, 7, Author
McAlonan, Grainne1, AuthorBatalle, Dafnis2, 20, Author more..
Affiliations:
1Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, ou_persistent22              
2Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King’s College London, United Kingdom, ou_persistent22              
3Department of Computer and Information Sciences, Faculty of Engineering and Environment, Northumbria University, Newcastle, United Kingdom, ou_persistent22              
4Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Wellcome Centre For Integrative Neuroimaging, University of Oxford, United Kingdom, ou_persistent22              
5Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid, Spain, ou_persistent22              
6Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, Madrid, Spain, ou_persistent22              
7MRC Centre for Neurodevelopmental Disorders, King's College London, United Kingdom, ou_persistent22              
8Division of Brain Sciences, Imperial College London, United Kingdom, ou_persistent22              
9UK Dementia Research Institute at Imperial College London, United Kingdom, ou_persistent22              
10Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, Finland, ou_persistent22              
11Turku Collegium for Science and Medicine and Technology, University of Turku, Finland, ou_persistent22              
12Department of Psychiatry, University of Turku, Finland, ou_persistent22              
13Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
14Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
15Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
16School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              
17Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, ou_persistent22              
18Department of Paediatric Neurosciences, Evelina London Children's Hospital, United Kingdom, ou_persistent22              
19Department of Bioengineering, Imperial College London, United Kingdom, ou_persistent22              
20Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, United Kingdom, ou_persistent22              

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Free keywords: Brain; Dynamical systems; Network models; Neuronal development
 Abstract: Brain dynamic functional connectivity characterises transient connections between brain regions. Features of brain dynamics have been linked to emotion and cognition in adult individuals, and atypical patterns have been associated with neurodevelopmental conditions such as autism. Although reliable functional brain networks have been consistently identified in neonates, little is known about the early development of dynamic functional connectivity. In this study we characterise dynamic functional connectivity with functional magnetic resonance imaging (fMRI) in the first few weeks of postnatal life in term-born (n = 324) and preterm-born (n = 66) individuals. We show that a dynamic landscape of brain connectivity is already established by the time of birth in the human brain, characterised by six transient states of neonatal functional connectivity with changing dynamics through the neonatal period. The pattern of dynamic connectivity is atypical in preterm-born infants, and associated with atypical social, sensory, and repetitive behaviours measured by the Quantitative Checklist for Autism in Toddlers (Q-CHAT) scores at 18 months of age.

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Language(s): eng - English
 Dates: 2023-02-282023-11-282024-02-082024-02-08
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/s41467-023-44050-z
PMID: 38331941
PMC: PMC10853532
 Degree: -

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Project name : -
Grant ID : 319456
Funding program : -
Funding organization : European Research Council (ERC)
Project name : This is only an excerpt. You can find the complete funding information on the article page.
Grant ID : -
Funding program : -
Funding organization : -

Source 1

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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 15 (1) Sequence Number: 16 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723