Bifidobacteria compensate for genotype in lactose tolerance

Fitzstevens, L; Liu, X; Ruaud, A; Schmidt, VT; Mbong Ngwese, M; Youngblut, ND; Rauch, J; Suzuki, T; Ha, NT; Arzamasov, A; Rodionov, D; Pfister, N; Thams, N; Adegbite, BR; Zinsou, JF; Esen, M; Velavan, TP; Adegnika, AA; Song, LH; Kremsner, P; Ostermann, A; Tyakht, AV; Ley, RE

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Bifidobacteria compensate for genotype in lactose tolerance

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Fitzstevens, L
Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;

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Liu, X
Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;

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Ruaud, A
Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;

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Schmidt, VT
Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;

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Mbong Ngwese, M
Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;

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Youngblut, ND
Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;

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Rauch, J
Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;

/persons/resource/persons270535

Suzuki, T
Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;

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Tyakht, AV
Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;
Mobile Genetic Elements in the Gut Microbiome of Human Populations Group, Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;

/persons/resource/persons270516

Ley, RE
Department Microbiome Science, Max Planck Institute for Biology Tübingen, Max Planck Society;

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Fitzstevens, L., Liu, X., Ruaud, A., Schmidt, V., Mbong Ngwese, M., Youngblut, N., Rauch, J., Suzuki, T., Ha, N., Arzamasov, A., Rodionov, D., Pfister, N., Thams, N., Adegbite, B., Zinsou, J., Esen, M., Velavan, T., Adegnika, A., Song, L., Kremsner, P., Ostermann, A., Tyakht, A., & Ley, R. (2024). Bifidobacteria compensate for genotype in lactose tolerance. Poster presented at 75th Mosbacher Kolloquium "The Microbiome - from Understanding to Modulation", Mosbach, Germany.

引用: https://hdl.handle.net/21.11116/0000-000F-04AB-C

要旨

The lactase-persistence (LP) genotype allows digestion of the milk sugar lactose in adults and confers lactose tolerance. Genetically lactase non-persistent (LNP) individuals can also be lactose tolerant, but responsible microbiota remain elusive. Here, we assessed lactose tolerance as H2-production in breath after lactose dose, LP/LNP genotype, and gut microbiome metagenomic diversity in 480 adults from Gabon (100% LNP), Vietnam (99% LNP), and Germany (23% LNP). In all three populations, ~ 13% of LNP were lactose tolerant though microbiomes differed. In-vitro lactose addition to stool showed low H2 production stemmed either from minimal breakdown of lactose, or breakdown producing metabolites of the Bifid shunt pathway - lactate and acetate - and the growth of Bifidobacterium. Our results indicate that Bifidobacterium can confer lactose tolerance across populations, including where the LP genotype is rare, and may have facilitated functional take-over by the human genome when dairying first began 12,000 years ago.